多數(shù)人對(duì)Neuralink這個(gè)名字并不熟悉,但這家初創(chuàng)公司其實(shí)也是埃隆·馬斯克創(chuàng)立的。Neuralink的主要開發(fā)技術(shù)在于“腦機(jī)接口”,通俗而言就是將人腦與電腦連接起來進(jìn)行交互。馬斯克曾在推特和播客上分享過很多暢想,宣稱這一技術(shù)可以緩解抑郁癥、治療強(qiáng)迫性神經(jīng)障礙、創(chuàng)傷性腦損傷等等,但Neuralink一直都很神秘,鮮少出現(xiàn)在公眾的視線當(dāng)中。
正因如此,這兩天出現(xiàn)了一個(gè)重磅消息:馬斯克宣布要在當(dāng)?shù)貢r(shí)間8月28日下午三點(diǎn)(北京時(shí)間8月29日清晨6點(diǎn))現(xiàn)場(chǎng)直播Neuralink腦機(jī)接口技術(shù)的“進(jìn)展情況”。
馬斯克在一年前曾向外界透露過Neuralink的冰山一角。2019年,Neuralink團(tuán)隊(duì)展示了一些搭載在細(xì)小探針上的微型電極,指出這些電極可以在損傷最小化的基礎(chǔ)上穿透大腦組織,幫助創(chuàng)傷性腦損傷患者恢復(fù)大腦功能,并表示該項(xiàng)研究已在鼠類及靈長(zhǎng)類動(dòng)物身上完成了試驗(yàn)。
那么Neuralink現(xiàn)在的研究進(jìn)展到底到了哪一步,又是否會(huì)實(shí)現(xiàn)馬斯克的預(yù)言呢?以下是筆者就近期所有信息梳理的詳細(xì)概要。
(Neuralink在)不久后就能將其技術(shù)植入人體
5月7日,馬斯克在播客上作客人氣節(jié)目《Joe Rogan Experience》時(shí)預(yù)測(cè),“Neuralink在一年內(nèi)就能將神經(jīng)鏈接植入到人體內(nèi)部。”不過這種植入技術(shù)并不新鮮,目前的臨床醫(yī)學(xué)已經(jīng)可以在治療癲癇和帕金森這類疾病的時(shí)候運(yùn)用這種方法了,只是風(fēng)險(xiǎn)較高,有可能會(huì)使患者大腦出血而亡。
美國(guó)國(guó)防高級(jí)研究計(jì)劃署生物技術(shù)辦公室前負(fù)責(zé)人賈斯汀·桑切斯估計(jì),全球大約有20萬人的大腦中攜帶著某種被植入的神經(jīng)技術(shù)。事實(shí)上,這種技術(shù)已經(jīng)相當(dāng)完備,以至于美國(guó)巴特爾紀(jì)念研究所甚至開發(fā)了一種可以幫助球手提升“揮桿速度”的神經(jīng)技術(shù)設(shè)備。
另外,馬斯克在當(dāng)期節(jié)目中還透露,“Neuralink會(huì)在2020年進(jìn)入人體實(shí)驗(yàn)階段?!边M(jìn)行人體實(shí)驗(yàn)也就意味著Neuralink需要獲得美國(guó)食品和藥物管理局的豁免,使其免于連續(xù)性的常規(guī)監(jiān)管范疇之內(nèi)。這種可能性并不大,但也不是并非完全沒有可能,因?yàn)榇竽X植入物獲得豁免的情況還是存有很多先例的,只是Neuralink可能要面臨更多額外的質(zhì)疑和挑戰(zhàn)。
據(jù)美國(guó)健康新聞網(wǎng)本周一的報(bào)道,Neuralink公司內(nèi)部的關(guān)系并不和諧,該報(bào)道援引Neuralink前員工的說法,稱“公司的企業(yè)文化很混亂,人才流動(dòng)很快。”
(Neuralink可以)有效治療上癮和抑郁癥狀
6月10日,一位推特用戶向馬斯克提問,“Neuralink的技術(shù)是否可以用來抑制大腦中的上癮癥狀和抑郁癥狀?!睂?duì)此,馬斯克的回答是:“當(dāng)然,這項(xiàng)技術(shù)即偉大又可怕?!?/p>
“在大腦中放置電極可以有效緩解上癮和抑郁?!边@一點(diǎn)一直都是所有神經(jīng)科學(xué)家所公認(rèn)的。除了Neuralink,還有很多研究者也在研究這一領(lǐng)域,其中就包括明尼蘇達(dá)大學(xué)的精神病學(xué)家和生物醫(yī)學(xué)工程師埃里卡·維奇教授。這種療法需要在大腦中的“內(nèi)囊”部位上放置電極,再通過刺激其與前額皮質(zhì)的連接來改善患者的感知及判斷等認(rèn)知功能。維奇表示,全球大約有200余名患者嘗試過這種治療抑郁癥的方法。
同時(shí),一些國(guó)家也嘗試在吸毒者的大腦中植入電極,以此抑制患者的毒癮。去年年底,美國(guó)的一位西佛吉尼亞州男子就在WVU Rockefeller神經(jīng)科學(xué)研究所接受了這一手術(shù),并在術(shù)后完全戒除了毒癮。本月初,另一名吸毒患者也接受了同樣的手術(shù)。
盡管現(xiàn)下的技術(shù)水平離廣泛普及還有一段距離,但這些領(lǐng)域?qū)τ贜euralink而言,可謂是勢(shì)在必得。在2018年一項(xiàng)關(guān)于腦深部刺激及其對(duì)抑郁癥影響的研究綜述中,科學(xué)家們表示,該項(xiàng)療法的結(jié)果“有很大潛力”,但這項(xiàng)技術(shù)仍處于實(shí)驗(yàn)性階段。“我和很多的精神病學(xué)醫(yī)生聊過這個(gè)方面,他們都希望能夠看到更有力的療效數(shù)據(jù)。”維奇說道。(財(cái)富中文網(wǎng))
編譯:陳怡軒 馮雨涵
多數(shù)人對(duì)Neuralink這個(gè)名字并不熟悉,但這家初創(chuàng)公司其實(shí)也是埃隆·馬斯克創(chuàng)立的。Neuralink的主要開發(fā)技術(shù)在于“腦機(jī)接口”,通俗而言就是將人腦與電腦連接起來進(jìn)行交互。馬斯克曾在推特和播客上分享過很多暢想,宣稱這一技術(shù)可以緩解抑郁癥、治療強(qiáng)迫性神經(jīng)障礙、創(chuàng)傷性腦損傷等等,但Neuralink一直都很神秘,鮮少出現(xiàn)在公眾的視線當(dāng)中。
正因如此,這兩天出現(xiàn)了一個(gè)重磅消息:馬斯克宣布要在當(dāng)?shù)貢r(shí)間8月28日下午三點(diǎn)(北京時(shí)間8月29日清晨6點(diǎn))現(xiàn)場(chǎng)直播Neuralink腦機(jī)接口技術(shù)的“進(jìn)展情況”。
馬斯克在一年前曾向外界透露過Neuralink的冰山一角。2019年,Neuralink團(tuán)隊(duì)展示了一些搭載在細(xì)小探針上的微型電極,指出這些電極可以在損傷最小化的基礎(chǔ)上穿透大腦組織,幫助創(chuàng)傷性腦損傷患者恢復(fù)大腦功能,并表示該項(xiàng)研究已在鼠類及靈長(zhǎng)類動(dòng)物身上完成了試驗(yàn)。
那么Neuralink現(xiàn)在的研究進(jìn)展到底到了哪一步,又是否會(huì)實(shí)現(xiàn)馬斯克的預(yù)言呢?以下是筆者就近期所有信息梳理的詳細(xì)概要。
(Neuralink在)不久后就能將其技術(shù)植入人體
5月7日,馬斯克在播客上作客人氣節(jié)目《Joe Rogan Experience》時(shí)預(yù)測(cè),“Neuralink在一年內(nèi)就能將神經(jīng)鏈接植入到人體內(nèi)部?!辈贿^這種植入技術(shù)并不新鮮,目前的臨床醫(yī)學(xué)已經(jīng)可以在治療癲癇和帕金森這類疾病的時(shí)候運(yùn)用這種方法了,只是風(fēng)險(xiǎn)較高,有可能會(huì)使患者大腦出血而亡。
美國(guó)國(guó)防高級(jí)研究計(jì)劃署生物技術(shù)辦公室前負(fù)責(zé)人賈斯汀·桑切斯估計(jì),全球大約有20萬人的大腦中攜帶著某種被植入的神經(jīng)技術(shù)。事實(shí)上,這種技術(shù)已經(jīng)相當(dāng)完備,以至于美國(guó)巴特爾紀(jì)念研究所甚至開發(fā)了一種可以幫助球手提升“揮桿速度”的神經(jīng)技術(shù)設(shè)備。
另外,馬斯克在當(dāng)期節(jié)目中還透露,“Neuralink會(huì)在2020年進(jìn)入人體實(shí)驗(yàn)階段。”進(jìn)行人體實(shí)驗(yàn)也就意味著Neuralink需要獲得美國(guó)食品和藥物管理局的豁免,使其免于連續(xù)性的常規(guī)監(jiān)管范疇之內(nèi)。這種可能性并不大,但也不是并非完全沒有可能,因?yàn)榇竽X植入物獲得豁免的情況還是存有很多先例的,只是Neuralink可能要面臨更多額外的質(zhì)疑和挑戰(zhàn)。
據(jù)美國(guó)健康新聞網(wǎng)本周一的報(bào)道,Neuralink公司內(nèi)部的關(guān)系并不和諧,該報(bào)道援引Neuralink前員工的說法,稱“公司的企業(yè)文化很混亂,人才流動(dòng)很快。”
(Neuralink可以)有效治療上癮和抑郁癥狀
6月10日,一位推特用戶向馬斯克提問,“Neuralink的技術(shù)是否可以用來抑制大腦中的上癮癥狀和抑郁癥狀?!睂?duì)此,馬斯克的回答是:“當(dāng)然,這項(xiàng)技術(shù)即偉大又可怕?!?/p>
“在大腦中放置電極可以有效緩解上癮和抑郁。”這一點(diǎn)一直都是所有神經(jīng)科學(xué)家所公認(rèn)的。除了Neuralink,還有很多研究者也在研究這一領(lǐng)域,其中就包括明尼蘇達(dá)大學(xué)的精神病學(xué)家和生物醫(yī)學(xué)工程師埃里卡·維奇教授。這種療法需要在大腦中的“內(nèi)囊”部位上放置電極,再通過刺激其與前額皮質(zhì)的連接來改善患者的感知及判斷等認(rèn)知功能。維奇表示,全球大約有200余名患者嘗試過這種治療抑郁癥的方法。
同時(shí),一些國(guó)家也嘗試在吸毒者的大腦中植入電極,以此抑制患者的毒癮。去年年底,美國(guó)的一位西佛吉尼亞州男子就在WVU Rockefeller神經(jīng)科學(xué)研究所接受了這一手術(shù),并在術(shù)后完全戒除了毒癮。本月初,另一名吸毒患者也接受了同樣的手術(shù)。
盡管現(xiàn)下的技術(shù)水平離廣泛普及還有一段距離,但這些領(lǐng)域?qū)τ贜euralink而言,可謂是勢(shì)在必得。在2018年一項(xiàng)關(guān)于腦深部刺激及其對(duì)抑郁癥影響的研究綜述中,科學(xué)家們表示,該項(xiàng)療法的結(jié)果“有很大潛力”,但這項(xiàng)技術(shù)仍處于實(shí)驗(yàn)性階段?!拔液秃芏嗟木癫W(xué)醫(yī)生聊過這個(gè)方面,他們都希望能夠看到更有力的療效數(shù)據(jù)?!本S奇說道。(財(cái)富中文網(wǎng))
編譯:陳怡軒 馮雨涵
Elon Musk has made plenty of claims about Neuralink, his brain-machine interface company. On Twitter and on podcasts, the billionaire has touted abilities that sound nothing short of miraculous: easing depression, helping with obsessive compulsive disorder and treating traumatic brain injuries.
Now, Neuralink, whose work has largely been shrouded in secrecy, is set to give a public “progress update” on Friday.
In the run-up to the big reveal, Musk has allowed some glimpses at the company’s technology. An early look came a year ago, when the Neuralink team showed off tiny electrodes on thin, flexible probes they said would be able to penetrate brain tissue with minimal damage, and ultimately help restore brain function to people with traumatic brain injuries. The team has already been placing them in rats and primates.
Will the devices actually be able to achieve the breakthroughs Musk says they can? Here’s a rundown of what we know so far about Musk’s startup—the most recent claims, the technology, and what neuroscientists say is actually possible.
Claim: Neuralink will soon be able to implant its technology in humans
On May 7, Musk appeared on the popular podcast, the Joe Rogan Experience, and made a distinctive claim about Neuralink: The startup would “be able to implant a neural link in less than a year in a person, I think.” The prediction is not actually as groundbreaking as it might sound. Musk was describing a procedure that happens fairly routinely to treat conditions such as epilepsy and Parkinson’s, despite potentially fatal risks such as brain hemorrhages.
Justin Sanchez, who helped fund research done by Neuralink scientists when he ran the biological technologies office at the Defense Advanced Research Projects Agency, estimates that about 200,000 people globally have some sort of neurotechnology implanted in their brain. In fact, the technology is so well developed at this point that the Battelle Memorial Institute, where Sanchez is a fellow, has developed a neurotechnology-based non-implanted device aimed at nothing more grandiose than helping people improve their golf swings.
The other important element of Musk’s statement was that Neuralink is on track for human trials by next year. To test so quickly in humans, the company would need to get an exemption from the normal multi-year regulatory process from the Food and Drug Administration. That may be possible—other brain implants have received exemptions. But Neuralink’s device could face additional challenges.
A report in health news site Stat News this week detailed internal tensions at Neuralink, citing former employees who said the company culture could be chaotic and that it quickly cycled through scientific talent. According to two anonymous former employees, it had explored possibly by passing the U.S. regulatory process by pursuing human trials in China or Russia.
Claim: Neuralink devices will be able to treat addiction and depression
On July 10, Musk took to Twitter with another notable statement. A Twitter user asked Musk if Neuralink could be used to retrain the part of the brain that causes addiction and depression. Musk replied, “For sure. This is both great & terrifying.”
Neuroscientists agree that placing electrodes in the brain could help mitigate those conditions. In fact, researchers beyond Neuralink are working on it now, including Alik Widge, a psychiatrist and biomedical engineer at the University of Minnesota. The treatment involves applying electrodes to a spot in the brain called the internal capsule, and works by stimulating connections to the prefrontal cortex to improve cognitive functions such as perception and judgment. About 200 patients worldwide have tried the technique for depression, Widge said.
In several countries opioid addicts have had electrodes implanted into the areas of the brain that control addiction. That includes the U.S., where a West Virginia man underwent the procedure late last year at WVU Rockefeller Neuroscience Institute. He has abstained from opioids since, a spokeswoman said. A second opioid patient underwent the same surgery earlier this month.
While there are hurdles to wide adoption, there is no reason Neuralink couldn’t push into these areas in the future. In a 2018 review of studies of deep brain stimulation and its effects on depression, scientists said the results “showed promise” but the technique remained experimental. “The psychiatrists I talk with say that they want to see much stronger efficacy data,” Widge said.