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這個國家用狗“嗅探”新冠病毒,比核酸檢測還準(zhǔn)

這個國家用狗“嗅探”新冠病毒,比核酸檢測還準(zhǔn)

David Meyer 2020-09-25
狗的嗅覺更加可靠,而且能更快得出結(jié)果。

以后抵達芬蘭赫爾辛基機場的旅客,將很快得到非??煽康男鹿诓《緳z測,執(zhí)行檢測的是嗅探犬。

這是到目前為止規(guī)模最大的一次利用狗嗅出新冠病毒的試驗;一個月前迪拜國際機場啟動了類似項目。另外,德國發(fā)布的研究顯示,狗檢測新冠病毒的準(zhǔn)確率接近94%。

9月23日開始的芬蘭試驗使用了四只嗅探犬,每次兩只,因為它們很容易疲勞。但執(zhí)行該試驗的赫爾辛基大學(xué)(University of Helsinki)研究人員表示,他們有10只經(jīng)過訓(xùn)練的嗅探犬,可以在機場充滿不同氣味的嘈雜環(huán)境中工作。

研究人員鼓勵旅客使用消毒紙巾提取皮膚汗液拭子(迪拜的試驗需要將塑料軟管放到旅客的腋下),并將樣本放到一個廣口瓶中。廣口瓶會通過墻上的洞遞給在一邊等待的嗅探犬。檢測只需要幾秒鐘即可完成。之后,受試者需要接受新冠病毒標(biāo)準(zhǔn)聚合酶鏈反應(yīng)(PCR)檢測,用于收集比較數(shù)據(jù)進行研究。

首席研究員安娜?耶爾姆-比約克曼告訴《財富》雜志,如果嗅探犬的檢測結(jié)果呈陽性,“我們會帶領(lǐng)乘客,保證他們接受PCR檢測?!狈姨m建議感染新冠病毒的旅客入境后進行自我隔離,但并沒有強制隔離制度。

“高度敏感”

試驗在9月23日開始,到歐洲時間下午早些時候,已經(jīng)進行了約50次檢測。耶爾姆-比約克曼表示,研究團隊預(yù)期每天進行約100次檢測,每500次測試會有1例陽性病例。

她說:“狗能夠檢出PCR檢出的所有陽性病例,還可以比PCR多檢測出5%左右的陽性病例。狗非常敏感。它能夠發(fā)現(xiàn)更多曾經(jīng)感染過新冠肺炎且體內(nèi)仍然殘留病毒的陽性病例,盡管他們已經(jīng)不再具有傳染性。而且,狗可以在患者出現(xiàn)臨床癥狀前提前一周將其檢測出來?!?/p>

狗竟然敏感到能夠檢測出已經(jīng)度過傳染期的人體內(nèi)的病毒,這是否有些夸張?

耶爾姆-比約克曼認(rèn)為這沒有任何問題。她說:“有些PCR檢測也可以做到這一點……我們之所以沒有改變截止點,是因為目前沒有有關(guān)人類傳染周期長度的研究。在有足夠多的科學(xué)證據(jù)支持某個截止點之前,我們會讓狗來告訴我們[已經(jīng)檢測出非常少量的病毒]。然后我們會再教它們:‘如果低于這個水平,就不需要告訴我們?!?/p>

耶爾姆-比約克曼的團隊從4月開始一直在進行初步試驗,在5月宣布試驗取得成功。但她們的研究結(jié)果還沒有發(fā)表任何經(jīng)過同行審議的論文,甚至沒有提交文章接受同行審議。她表示,當(dāng)前情況緊急,因此她的團隊直接開始試點。

她說:“我們知道用狗進行檢測能夠成功。我們在五年前就開始進行這項研究,訓(xùn)練它們[檢測]癌癥等疾病。我們認(rèn)為在此次疫情期間,對于芬蘭最重要的是可以提供良好的檢測。狗的檢測準(zhǔn)確率高于PCR檢測。雖然我們完全顛倒了科研的步驟,但在新冠疫情期間,我們知道完成同行審議需要三個月時間,因此我們還沒有發(fā)表經(jīng)過同行審議的論文,就首先進行了實際操作。”

增加信心

理論上,赫爾辛基機場使用的技術(shù)能夠快速正式推廣。然而,耶爾姆-比約克曼表示,要允許狗近距離嗅探旅客,而不是在另外一個房間嗅探樣本,需要芬蘭修訂立法。比如在音樂廳入口這種環(huán)境中,狗可以像傳統(tǒng)嗅探犬一樣工作。

受到新冠疫情的沖擊,航空業(yè)非??释屓藗冎匦逻x擇乘飛機出行。病毒檢測對保證旅客和邊防部門的信心都至關(guān)重要,而且考慮到大型機場的乘客吞吐量,速度是關(guān)鍵。

同樣在9月23日,路透社報道稱,漢莎航空(Lufthansa)正在與藥企羅氏(Roche)談判部署抗原檢測??乖瓩z測比PCR檢測的速度更快,成本更低,只要15分鐘左右就能夠得出結(jié)果(PCR檢測需要幾個小時)。

意大利航空(Alitalia)甚至開通了羅馬與米蘭之間的航班,專門服務(wù)抗原檢測呈陰性證明體內(nèi)沒有病毒的旅客。

但抗原檢測的假陰性比例高于PCR檢測。似乎依靠狗的嗅覺更加可靠,而且可以更快得出結(jié)果。這種測試能夠自動完成。一家法國醫(yī)院準(zhǔn)備大量部署非常昂貴的呼吸式酒精測試儀用于病毒檢測,幾秒鐘之內(nèi)就可以得出結(jié)果。這種設(shè)備最初被設(shè)計用于大氣科學(xué)。但嗅探犬的體型更小、成本更低,而且已經(jīng)能夠廣泛部署。(財富中文網(wǎng))

翻譯:劉進龍

審校:汪皓

以后抵達芬蘭赫爾辛基機場的旅客,將很快得到非??煽康男鹿诓《緳z測,執(zhí)行檢測的是嗅探犬。

這是到目前為止規(guī)模最大的一次利用狗嗅出新冠病毒的試驗;一個月前迪拜國際機場啟動了類似項目。另外,德國發(fā)布的研究顯示,狗檢測新冠病毒的準(zhǔn)確率接近94%。

9月23日開始的芬蘭試驗使用了四只嗅探犬,每次兩只,因為它們很容易疲勞。但執(zhí)行該試驗的赫爾辛基大學(xué)(University of Helsinki)研究人員表示,他們有10只經(jīng)過訓(xùn)練的嗅探犬,可以在機場充滿不同氣味的嘈雜環(huán)境中工作。

研究人員鼓勵旅客使用消毒紙巾提取皮膚汗液拭子(迪拜的試驗需要將塑料軟管放到旅客的腋下),并將樣本放到一個廣口瓶中。廣口瓶會通過墻上的洞遞給在一邊等待的嗅探犬。檢測只需要幾秒鐘即可完成。之后,受試者需要接受新冠病毒標(biāo)準(zhǔn)聚合酶鏈反應(yīng)(PCR)檢測,用于收集比較數(shù)據(jù)進行研究。

首席研究員安娜?耶爾姆-比約克曼告訴《財富》雜志,如果嗅探犬的檢測結(jié)果呈陽性,“我們會帶領(lǐng)乘客,保證他們接受PCR檢測。”芬蘭建議感染新冠病毒的旅客入境后進行自我隔離,但并沒有強制隔離制度。

“高度敏感”

試驗在9月23日開始,到歐洲時間下午早些時候,已經(jīng)進行了約50次檢測。耶爾姆-比約克曼表示,研究團隊預(yù)期每天進行約100次檢測,每500次測試會有1例陽性病例。

她說:“狗能夠檢出PCR檢出的所有陽性病例,還可以比PCR多檢測出5%左右的陽性病例。狗非常敏感。它能夠發(fā)現(xiàn)更多曾經(jīng)感染過新冠肺炎且體內(nèi)仍然殘留病毒的陽性病例,盡管他們已經(jīng)不再具有傳染性。而且,狗可以在患者出現(xiàn)臨床癥狀前提前一周將其檢測出來?!?/p>

狗竟然敏感到能夠檢測出已經(jīng)度過傳染期的人體內(nèi)的病毒,這是否有些夸張?

耶爾姆-比約克曼認(rèn)為這沒有任何問題。她說:“有些PCR檢測也可以做到這一點……我們之所以沒有改變截止點,是因為目前沒有有關(guān)人類傳染周期長度的研究。在有足夠多的科學(xué)證據(jù)支持某個截止點之前,我們會讓狗來告訴我們[已經(jīng)檢測出非常少量的病毒]。然后我們會再教它們:‘如果低于這個水平,就不需要告訴我們?!?/p>

耶爾姆-比約克曼的團隊從4月開始一直在進行初步試驗,在5月宣布試驗取得成功。但她們的研究結(jié)果還沒有發(fā)表任何經(jīng)過同行審議的論文,甚至沒有提交文章接受同行審議。她表示,當(dāng)前情況緊急,因此她的團隊直接開始試點。

她說:“我們知道用狗進行檢測能夠成功。我們在五年前就開始進行這項研究,訓(xùn)練它們[檢測]癌癥等疾病。我們認(rèn)為在此次疫情期間,對于芬蘭最重要的是可以提供良好的檢測。狗的檢測準(zhǔn)確率高于PCR檢測。雖然我們完全顛倒了科研的步驟,但在新冠疫情期間,我們知道完成同行審議需要三個月時間,因此我們還沒有發(fā)表經(jīng)過同行審議的論文,就首先進行了實際操作。”

增加信心

理論上,赫爾辛基機場使用的技術(shù)能夠快速正式推廣。然而,耶爾姆-比約克曼表示,要允許狗近距離嗅探旅客,而不是在另外一個房間嗅探樣本,需要芬蘭修訂立法。比如在音樂廳入口這種環(huán)境中,狗可以像傳統(tǒng)嗅探犬一樣工作。

受到新冠疫情的沖擊,航空業(yè)非??释屓藗冎匦逻x擇乘飛機出行。病毒檢測對保證旅客和邊防部門的信心都至關(guān)重要,而且考慮到大型機場的乘客吞吐量,速度是關(guān)鍵。

同樣在9月23日,路透社報道稱,漢莎航空(Lufthansa)正在與藥企羅氏(Roche)談判部署抗原檢測。抗原檢測比PCR檢測的速度更快,成本更低,只要15分鐘左右就能夠得出結(jié)果(PCR檢測需要幾個小時)。

意大利航空(Alitalia)甚至開通了羅馬與米蘭之間的航班,專門服務(wù)抗原檢測呈陰性證明體內(nèi)沒有病毒的旅客。

但抗原檢測的假陰性比例高于PCR檢測。似乎依靠狗的嗅覺更加可靠,而且可以更快得出結(jié)果。這種測試能夠自動完成。一家法國醫(yī)院準(zhǔn)備大量部署非常昂貴的呼吸式酒精測試儀用于病毒檢測,幾秒鐘之內(nèi)就可以得出結(jié)果。這種設(shè)備最初被設(shè)計用于大氣科學(xué)。但嗅探犬的體型更小、成本更低,而且已經(jīng)能夠廣泛部署。(財富中文網(wǎng))

翻譯:劉進龍

審校:汪皓

For the rest of this year, passengers arriving at Finland’s Helsinki Airport will be able to get quick, apparently very reliable coronavirus tests from…dogs.

It’s one of the biggest trials so far in the use of dogs to sniff out SARS-CoV-2; a similar test has been underway for a month at Dubai International, and already published research from Germany indicates dogs have a detection rate of around 94% for the virus.

In the Finnish trial, which began September 23, four canines are being used—two at a time; they tire easily—though the University of Helsinki researchers behind the scheme say they have 10 that have been trained and can be relied upon to work in a noisy airport environment that is full of different smells.

Passengers are invited to take simple sweat swabs from their own skin using sterile tissue (the Dubai trial involves sticking plastic tubes into people’s armpits), then drop the tissue into a jar that is passed through a hole in the wall to the waiting dog. The test takes a few seconds. The subjects are then asked to take a standard polymerase chain reaction (PCR) test for the coronavirus, so comparative data can be gathered for the study.

If the canine test comes back positive, “we take them by the hand and see 100% that they go to the PCR test as well,” lead researcher Anna Hielm-Bj?rkman told Fortune. People arriving in Finland with the coronavirus are encouraged to self-isolate, though the country has no heavily enforced quarantining system for such cases.

“So much more sensitive”

The trial began September 23, and early in the European afternoon around 50 tests had already been conducted. Hielm-Bj?rkman said the team expected to conduct around 100 tests a day and to see around one positive case in every 500 tests.

“It finds all the positives that the PCR finds and then [around] 5% more positives than the PCR. The dog is so much more sensitive,” she said. “It finds more positives where people have had the disease and still have the virus in their body, even though they’re not contagious anymore. Also what it’s able to [do] is it can find the positive ones up to one week before they get their clinical symptoms.”

If the dogs are so sensitive that they can detect the virus in people who have passed through the contagious stage, is that not overdoing it?

Not a problem, said Hielm-Bj?rkman: “Some PCR tests do the same thing…The reason we haven’t changed the cutoff point yet is there is really no research yet on how long people are contagious. We will let the dogs tell us [that very small amounts of the virus have been detected] until there is enough science to back up a cutoff point. Then we’ll teach them again: ‘If it’s lower than this, you don't need to tell us.’”

Hielm-Bj?rkman's team has been conducting preliminary tests since April, and first announced success in May. Although it has not yet produced any peer-reviewed paper about its findings—or indeed submitted an article for peer review—she said the urgency of the situation had led the team to move straight to this pilot.

“We know the dogs work,” she said. “We’ve been doing this research for five years before, training them [to detect] cancer and other diseases. We thought in this time of an epidemic, the most important thing for Finland at the moment is getting these good tests. Dogs are superior to PCR tests. It’s totally backwards, but in a time of COVID, knowing it takes three months to get something peer reviewed, we went operational before we had a peer-reviewed article.”

Instilling confidence

In theory, the technique being used at Helsinki Airport could be formally rolled out quite quickly. However, a scenario involving dogs sniffing passengers up close, rather than sniffing their samples in another room, would require a legislative change in Finland—this would be relevant in settings such as the entrance to a concert hall, where the dogs would operate like traditional sniffer dogs, Hielm-Bj?rkman said.

The aviation sector, which has been hammered by the COVID-19 pandemic, is desperate to get people back on flights. Testing is crucial both for passenger confidence and for the confidence of border authorities, and—given the volume of passengers passing through large airports—speed is of the essence.

Also on September 23, Reuters reported that Lufthansa is talking to drugmaker Roche about the deployment of antigen tests—a faster and cheaper alternative to PCR tests—that produce results in 15 minutes or so (PCR tests take hours).

Alitalia is even running special flights between Rome and Milan that are reserved for passengers that have had negative antigen tests, indicating that they do not have the virus in their systems.

But antigen tests are known to produce more false negatives than PCR tests. It appears the smell-based technique is more reliable, and even quicker in producing results. It’s a test that can be automated—a French hospital is preparing to deploy an enormous and very expensive Breathalyzer, originally designed for atmospheric science, to get results within seconds—but sniffer dogs are smaller, cheaper, and already widely available.

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