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大型藥企依靠人工智能掌握行業(yè)動(dòng)態(tài)

STEPHANIE CAIN
2024-03-29

競(jìng)爭(zhēng)優(yōu)勢(shì)是各行各業(yè)成功的必要條件,這一點(diǎn)在制藥行業(yè)尤為明顯。

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全球頂級(jí)藥企利用咨詢公司提供人工智能驅(qū)動(dòng)的情報(bào),以加快藥品上市。圖片來源:GETTY IMAGES

競(jìng)爭(zhēng)優(yōu)勢(shì)是各行各業(yè)成功的必要條件,這一點(diǎn)在制藥行業(yè)尤為明顯。藥企投入數(shù)億美元和大量時(shí)間,研究如何搶在競(jìng)爭(zhēng)對(duì)手之前完成臨床試驗(yàn)和藥品上市。

但它們不會(huì)單打獨(dú)斗。

在這些頂級(jí)藥企和小型生物科技公司背后,有Lifescience Dynamics等咨詢機(jī)構(gòu)提供來自數(shù)十名學(xué)者和分析師的第三方信譽(yù)保證,而且更重要的是,它們提供了有價(jià)值的工具,可以為藥企帶來深刻的見解和建議,以加速產(chǎn)品研發(fā)和更快獲得美國(guó)食品藥品管理局(FDA)的批準(zhǔn)。

Lifescience Dynamics公司高級(jí)顧問侯賽因·賈法爾解釋稱:“制藥是一個(gè)數(shù)據(jù)驅(qū)動(dòng)的行業(yè)。為了向我們的客戶提供咨詢,我們需要獲取盡可能多的數(shù)據(jù)?!彼窃摴静捎萌斯ぶ悄艿闹饕?fù)責(zé)人。

Lifescience Dynamics的實(shí)力源于它的五款主要科技產(chǎn)品,這些產(chǎn)品整合了人工智能元素,包括機(jī)器學(xué)習(xí)、大語(yǔ)言模型和生成式AI等,可以計(jì)算大數(shù)據(jù)集、匯總信息和提供明智的建議。

一款新藥從發(fā)現(xiàn)、開發(fā)到最終上市,平均需要8至12年時(shí)間。Lifescience Dynamics創(chuàng)始人兼總裁拉法特·拉赫瑪尼解釋稱,在這個(gè)過程中,制藥團(tuán)隊(duì)要做出許多決策,這些決策通常是基于“相互矛盾、有限或零星的數(shù)據(jù)”。為了最大程度降低風(fēng)險(xiǎn),藥企必須向第三方研究機(jī)構(gòu)尋求幫助,以驗(yàn)證它們的數(shù)據(jù)和決策。因此,拉赫瑪尼才會(huì)在二十年前創(chuàng)建了Lifescience Dynamics。他之前曾任職于禮來(Eli Lilly)及其他醫(yī)療保健咨詢機(jī)構(gòu)。

在過去幾年人工智能迎來飛速發(fā)展之前,他的團(tuán)隊(duì)的許多任務(wù)依舊要靠人工來完成,每項(xiàng)任務(wù)每年都要投入數(shù)千個(gè)小時(shí)的人力。該公司的130多家客戶,其中大多數(shù)來自全球排名前20的制藥公司,因此這是一項(xiàng)艱巨的任務(wù),但也存在更多出現(xiàn)人為錯(cuò)誤的機(jī)會(huì),對(duì)于受到嚴(yán)格監(jiān)管的制藥行業(yè)來說,這是一個(gè)重大挑戰(zhàn)。

現(xiàn)在,在人工智能的協(xié)助下,有些任務(wù)只需要10分鐘就能完成,而且對(duì)這些任務(wù)的信心通常高達(dá)100%。雖然拉赫瑪尼一直認(rèn)為L(zhǎng)ifescience Dynamics是一家諳熟技術(shù)的公司,但這種心態(tài)真正的好處體現(xiàn)在其對(duì)人工智能的應(yīng)用上。

賈法爾發(fā)現(xiàn)受影響最大的業(yè)務(wù)領(lǐng)域或許并不引人注目,卻給客戶和他自己的團(tuán)隊(duì)創(chuàng)造了無與倫比的價(jià)值,其中包括數(shù)據(jù)收集、數(shù)據(jù)分析和數(shù)據(jù)可視化等。跟蹤臨床試驗(yàn)對(duì)于制藥行業(yè)而言至關(guān)重要,尤其是競(jìng)爭(zhēng)對(duì)手的試驗(yàn)進(jìn)展。賈法爾解釋稱,他的團(tuán)隊(duì)以前會(huì)使用“龐大的”Excel數(shù)據(jù)表,團(tuán)隊(duì)成員需要手動(dòng)錄入數(shù)據(jù),閱讀在線最新內(nèi)容,然后更新數(shù)據(jù)表。2021年,他們推出了一款機(jī)器學(xué)習(xí)模型,可自動(dòng)從clinicaltrials.gov等注冊(cè)網(wǎng)站抓取信息,并持續(xù)更新。他說道,實(shí)時(shí)數(shù)據(jù)自動(dòng)化是該公司優(yōu)化流程和提高效率以滿足客戶預(yù)期的關(guān)鍵。

此外,他負(fù)責(zé)的一個(gè)項(xiàng)目會(huì)從重要醫(yī)療行業(yè)會(huì)議上,抓取有關(guān)研討會(huì)和藥物更新的有價(jià)值的信息。許多活動(dòng)的參會(huì)人數(shù)超過70,000人,有時(shí)候會(huì)有5,000多場(chǎng)研討會(huì)。在使用人工智能之前,匯總和分析數(shù)據(jù)是一項(xiàng)艱巨的任務(wù);現(xiàn)在,Lifescience Dynamics的模型會(huì)自動(dòng)提取摘要和細(xì)節(jié),甚至可以總結(jié)和推薦值得參加的會(huì)議。

Lifescience Dynamics收集的見解都存儲(chǔ)于客戶的門戶網(wǎng)站上,客戶可以隨時(shí)登陸以全面了解他們的競(jìng)爭(zhēng)情報(bào)項(xiàng)目、臨床試驗(yàn)數(shù)據(jù)和藥物數(shù)據(jù)。賈法爾解釋稱,公司目前正在基于這些數(shù)據(jù)開發(fā)人工智能模型,使用自然語(yǔ)言處理客戶查詢,并更好地理解結(jié)果。它不僅能夠提高客戶-顧問關(guān)系的透明度,還能讓Lifescience團(tuán)隊(duì)免于應(yīng)對(duì)客戶提出的耗時(shí)漫長(zhǎng)、占用大量資源的問題。

最近,賈法爾和他的團(tuán)隊(duì)注意到生成式人工智能所帶來的好處,特別開發(fā)了在線調(diào)查,使獨(dú)立醫(yī)生可以參與調(diào)查,發(fā)表對(duì)某些藥物的評(píng)論和建議。作為同行審議過程的一個(gè)重要組成部分,藥企會(huì)獲取醫(yī)生對(duì)于潛在藥物現(xiàn)實(shí)的、面向患者的意見。對(duì)賈法爾而言,生成式人工智能和大語(yǔ)言模型可幫助他創(chuàng)建支持醫(yī)生在線討論的調(diào)查模板,并識(shí)別適合特定調(diào)查的專家。

賈法爾表示:“這項(xiàng)工作以前完全由人工完成,而且我們只能依靠自己的經(jīng)驗(yàn)和專業(yè)知識(shí)。但通過使用人工智能,我們可以向它提供我們所期望的討論指南的背景,然后它就會(huì)生成一個(gè)非常有用的模板,幫我們完成最終指南80%的工作?!?/p>

剩余20%的工作由該團(tuán)隊(duì)手動(dòng)完成。

雖然人工智能讓公司大獲成功,但賈法爾和拉赫瑪尼知道未來還有更大的挑戰(zhàn)。賈法爾計(jì)劃創(chuàng)建適用于其所在領(lǐng)域的人工智能模型。雖然Lifescience Dynamics可以從其歷史數(shù)據(jù)中提取信息,但真正的價(jià)值源于業(yè)內(nèi)的更多共享數(shù)據(jù)。他解釋稱,很可惜,對(duì)醫(yī)療保健行業(yè)的嚴(yán)格監(jiān)管和患者信息的保密性,以及醫(yī)療行業(yè)的競(jìng)爭(zhēng)之激烈,意味著藥企出于多種原因不愿意公開自己的數(shù)據(jù)。一種令人擔(dān)憂的情況是,公司繼續(xù)獨(dú)立開發(fā),而不是在全球共享集體數(shù)據(jù),以便于人工智能可以快速學(xué)習(xí)。與其他領(lǐng)域相比,制藥行業(yè)可分享的數(shù)據(jù)確實(shí)更少。

拉赫瑪尼預(yù)測(cè),制藥行業(yè)有關(guān)人工智能的爭(zhēng)論可能需要更長(zhǎng)時(shí)間才能塵埃落定。他表示,盡管人工智能的出現(xiàn)令人興奮和激動(dòng),但舊的承諾和不支持這項(xiàng)技術(shù)的領(lǐng)導(dǎo)者依舊存在。但他對(duì)人工智能的未來充滿了信心,他認(rèn)為人工智能是能夠幫助整個(gè)行業(yè)成功的工具。

拉赫瑪尼說道:“我能理解為什么他們不愿意使用人工智能,但這確實(shí)限制了人工智能的應(yīng)用。我們的客戶雇傭我們,希望我們能在最短的時(shí)間內(nèi)以最低的成本,為他們提供見解,并將見解轉(zhuǎn)變成遠(yuǎn)見。這些人工智能工具能最大限度發(fā)揮數(shù)據(jù)的價(jià)值,讓數(shù)據(jù)變得生動(dòng)起來?!保ㄘ?cái)富中文網(wǎng))

翻譯:劉進(jìn)龍

審校:汪皓

競(jìng)爭(zhēng)優(yōu)勢(shì)是各行各業(yè)成功的必要條件,這一點(diǎn)在制藥行業(yè)尤為明顯。藥企投入數(shù)億美元和大量時(shí)間,研究如何搶在競(jìng)爭(zhēng)對(duì)手之前完成臨床試驗(yàn)和藥品上市。

但它們不會(huì)單打獨(dú)斗。

在這些頂級(jí)藥企和小型生物科技公司背后,有Lifescience Dynamics等咨詢機(jī)構(gòu)提供來自數(shù)十名學(xué)者和分析師的第三方信譽(yù)保證,而且更重要的是,它們提供了有價(jià)值的工具,可以為藥企帶來深刻的見解和建議,以加速產(chǎn)品研發(fā)和更快獲得美國(guó)食品藥品管理局(FDA)的批準(zhǔn)。

Lifescience Dynamics公司高級(jí)顧問侯賽因·賈法爾解釋稱:“制藥是一個(gè)數(shù)據(jù)驅(qū)動(dòng)的行業(yè)。為了向我們的客戶提供咨詢,我們需要獲取盡可能多的數(shù)據(jù)?!彼窃摴静捎萌斯ぶ悄艿闹饕?fù)責(zé)人。

Lifescience Dynamics的實(shí)力源于它的五款主要科技產(chǎn)品,這些產(chǎn)品整合了人工智能元素,包括機(jī)器學(xué)習(xí)、大語(yǔ)言模型和生成式AI等,可以計(jì)算大數(shù)據(jù)集、匯總信息和提供明智的建議。

一款新藥從發(fā)現(xiàn)、開發(fā)到最終上市,平均需要8至12年時(shí)間。Lifescience Dynamics創(chuàng)始人兼總裁拉法特·拉赫瑪尼解釋稱,在這個(gè)過程中,制藥團(tuán)隊(duì)要做出許多決策,這些決策通常是基于“相互矛盾、有限或零星的數(shù)據(jù)”。為了最大程度降低風(fēng)險(xiǎn),藥企必須向第三方研究機(jī)構(gòu)尋求幫助,以驗(yàn)證它們的數(shù)據(jù)和決策。因此,拉赫瑪尼才會(huì)在二十年前創(chuàng)建了Lifescience Dynamics。他之前曾任職于禮來(Eli Lilly)及其他醫(yī)療保健咨詢機(jī)構(gòu)。

在過去幾年人工智能迎來飛速發(fā)展之前,他的團(tuán)隊(duì)的許多任務(wù)依舊要靠人工來完成,每項(xiàng)任務(wù)每年都要投入數(shù)千個(gè)小時(shí)的人力。該公司的130多家客戶,其中大多數(shù)來自全球排名前20的制藥公司,因此這是一項(xiàng)艱巨的任務(wù),但也存在更多出現(xiàn)人為錯(cuò)誤的機(jī)會(huì),對(duì)于受到嚴(yán)格監(jiān)管的制藥行業(yè)來說,這是一個(gè)重大挑戰(zhàn)。

現(xiàn)在,在人工智能的協(xié)助下,有些任務(wù)只需要10分鐘就能完成,而且對(duì)這些任務(wù)的信心通常高達(dá)100%。雖然拉赫瑪尼一直認(rèn)為L(zhǎng)ifescience Dynamics是一家諳熟技術(shù)的公司,但這種心態(tài)真正的好處體現(xiàn)在其對(duì)人工智能的應(yīng)用上。

賈法爾發(fā)現(xiàn)受影響最大的業(yè)務(wù)領(lǐng)域或許并不引人注目,卻給客戶和他自己的團(tuán)隊(duì)創(chuàng)造了無與倫比的價(jià)值,其中包括數(shù)據(jù)收集、數(shù)據(jù)分析和數(shù)據(jù)可視化等。跟蹤臨床試驗(yàn)對(duì)于制藥行業(yè)而言至關(guān)重要,尤其是競(jìng)爭(zhēng)對(duì)手的試驗(yàn)進(jìn)展。賈法爾解釋稱,他的團(tuán)隊(duì)以前會(huì)使用“龐大的”Excel數(shù)據(jù)表,團(tuán)隊(duì)成員需要手動(dòng)錄入數(shù)據(jù),閱讀在線最新內(nèi)容,然后更新數(shù)據(jù)表。2021年,他們推出了一款機(jī)器學(xué)習(xí)模型,可自動(dòng)從clinicaltrials.gov等注冊(cè)網(wǎng)站抓取信息,并持續(xù)更新。他說道,實(shí)時(shí)數(shù)據(jù)自動(dòng)化是該公司優(yōu)化流程和提高效率以滿足客戶預(yù)期的關(guān)鍵。

此外,他負(fù)責(zé)的一個(gè)項(xiàng)目會(huì)從重要醫(yī)療行業(yè)會(huì)議上,抓取有關(guān)研討會(huì)和藥物更新的有價(jià)值的信息。許多活動(dòng)的參會(huì)人數(shù)超過70,000人,有時(shí)候會(huì)有5,000多場(chǎng)研討會(huì)。在使用人工智能之前,匯總和分析數(shù)據(jù)是一項(xiàng)艱巨的任務(wù);現(xiàn)在,Lifescience Dynamics的模型會(huì)自動(dòng)提取摘要和細(xì)節(jié),甚至可以總結(jié)和推薦值得參加的會(huì)議。

Lifescience Dynamics收集的見解都存儲(chǔ)于客戶的門戶網(wǎng)站上,客戶可以隨時(shí)登陸以全面了解他們的競(jìng)爭(zhēng)情報(bào)項(xiàng)目、臨床試驗(yàn)數(shù)據(jù)和藥物數(shù)據(jù)。賈法爾解釋稱,公司目前正在基于這些數(shù)據(jù)開發(fā)人工智能模型,使用自然語(yǔ)言處理客戶查詢,并更好地理解結(jié)果。它不僅能夠提高客戶-顧問關(guān)系的透明度,還能讓Lifescience團(tuán)隊(duì)免于應(yīng)對(duì)客戶提出的耗時(shí)漫長(zhǎng)、占用大量資源的問題。

最近,賈法爾和他的團(tuán)隊(duì)注意到生成式人工智能所帶來的好處,特別開發(fā)了在線調(diào)查,使獨(dú)立醫(yī)生可以參與調(diào)查,發(fā)表對(duì)某些藥物的評(píng)論和建議。作為同行審議過程的一個(gè)重要組成部分,藥企會(huì)獲取醫(yī)生對(duì)于潛在藥物現(xiàn)實(shí)的、面向患者的意見。對(duì)賈法爾而言,生成式人工智能和大語(yǔ)言模型可幫助他創(chuàng)建支持醫(yī)生在線討論的調(diào)查模板,并識(shí)別適合特定調(diào)查的專家。

賈法爾表示:“這項(xiàng)工作以前完全由人工完成,而且我們只能依靠自己的經(jīng)驗(yàn)和專業(yè)知識(shí)。但通過使用人工智能,我們可以向它提供我們所期望的討論指南的背景,然后它就會(huì)生成一個(gè)非常有用的模板,幫我們完成最終指南80%的工作?!?/p>

剩余20%的工作由該團(tuán)隊(duì)手動(dòng)完成。

雖然人工智能讓公司大獲成功,但賈法爾和拉赫瑪尼知道未來還有更大的挑戰(zhàn)。賈法爾計(jì)劃創(chuàng)建適用于其所在領(lǐng)域的人工智能模型。雖然Lifescience Dynamics可以從其歷史數(shù)據(jù)中提取信息,但真正的價(jià)值源于業(yè)內(nèi)的更多共享數(shù)據(jù)。他解釋稱,很可惜,對(duì)醫(yī)療保健行業(yè)的嚴(yán)格監(jiān)管和患者信息的保密性,以及醫(yī)療行業(yè)的競(jìng)爭(zhēng)之激烈,意味著藥企出于多種原因不愿意公開自己的數(shù)據(jù)。一種令人擔(dān)憂的情況是,公司繼續(xù)獨(dú)立開發(fā),而不是在全球共享集體數(shù)據(jù),以便于人工智能可以快速學(xué)習(xí)。與其他領(lǐng)域相比,制藥行業(yè)可分享的數(shù)據(jù)確實(shí)更少。

拉赫瑪尼預(yù)測(cè),制藥行業(yè)有關(guān)人工智能的爭(zhēng)論可能需要更長(zhǎng)時(shí)間才能塵埃落定。他表示,盡管人工智能的出現(xiàn)令人興奮和激動(dòng),但舊的承諾和不支持這項(xiàng)技術(shù)的領(lǐng)導(dǎo)者依舊存在。但他對(duì)人工智能的未來充滿了信心,他認(rèn)為人工智能是能夠幫助整個(gè)行業(yè)成功的工具。

拉赫瑪尼說道:“我能理解為什么他們不愿意使用人工智能,但這確實(shí)限制了人工智能的應(yīng)用。我們的客戶雇傭我們,希望我們能在最短的時(shí)間內(nèi)以最低的成本,為他們提供見解,并將見解轉(zhuǎn)變成遠(yuǎn)見。這些人工智能工具能最大限度發(fā)揮數(shù)據(jù)的價(jià)值,讓數(shù)據(jù)變得生動(dòng)起來?!保ㄘ?cái)富中文網(wǎng))

翻譯:劉進(jìn)龍

審校:汪皓

A competitive advantage is necessary for success across industries, but maybe nowhere so much as pharmaceuticals, where companies spend millions of dollars and thousands of hours researching how to get their developments through clinical trials and onto the market before their competitors.

But they don’t do it alone.

Behind the top pharmaceutical companies, as well as smaller biotech firms, consulting agencies like Lifescience Dynamics provide third-party credibility from dozens of academic scholars and analysts and, more important, supply valuable tools to provide pharma companies with insights and recommendations to speed up the development of their products and gain FDA approval.

“Pharma is a data-driven business,” explains Hussein Jaafar, a senior consultant at Lifescience Dynamics, who has largely led the charge on the team’s adoption of artificial intelligence. “To be able to consult our clients, we need to have access to as much data as possible.”

The power from Lifescience Dynamics comes from its five main technology products, which incorporate elements of artificial intelligence—including machine learning, large language models, and generative AI—to compute large data sets, amass information, and make educated recommendations.

On average, it takes eight to 12 years to discover, develop, and ultimately launch a drug. Along the way, pharmaceutical teams make several decisions, often under “conflicting, limited, or patchy data,” explains Lifescience Dynamics founder and president Rafaat Rahmani. To minimize risk, pharma companies are required to seek third-party research firms to validate their data and decision-making. That’s why Rahmani, who previously worked for Eli Lilly and other health care consultancies, started Lifescience Dynamics two decades ago.

Until the past few years with the explosion of AI capabilities, many of this team’s tasks were still done by hand, amassing thousands of hours of labor each year each. With more than 130 clients that hail from the majority of the world’s top 20 pharmaceutical companies, that was a hefty task but also left more opportunities for human error, a major challenge for something as regulated as the pharma industry.

Now, with the assistance of AI, some tasks take just 10 minutes, and confidence in the task is often 100%. Though Rahmani has long considered Lifescience Dynamics a technology-savvy company, the real benefit of that mentality has shown in its use of AI.

The areas of business where Jaafar has seen the biggest impact are possibly less sexy but unparalleled in value to clients and his own team: data collection, data analysis, and data visualization. Critical to the pharmaceutical industry is the tracking of clinical trials, especially by competitors. Jaafar explains that the team used to have “giant” Excel spreadsheets that a team member would need to physically click through, read updates online, then update the sheet. In 2021, they rolled out a machine-learning model that does this for the team by pulling information automatically from online registries like clinicaltrials.gov and continuously adding updates. The live feed automation, he says, has been key to streamlining their processes and increasing their effectiveness in meeting client expectations.

Similarly, he spearheaded a project that scrapes valuable information about sessions and drug updates from the major medical industry conference. Many of these events draw in upwards of 70,000 people with sometimes more than 5,000 sessions. It was a beast for a team to consolidate and analyze data before AI; now, the Lifescience Dynamics model pulls abstracts and details automatically, even summarizing and recommending sessions for attendance.

The insights gathered by Lifescience Dynamics all live in a client portal, allowing clients at any time to log on for a full look at their competitive intelligence projects, clinical trial data, and drug data. Jaafar explains that they are currently building AI models on top of that data to help clients query using natural language better understand the results. It not only adds transparency in the client-consultant relationship, but saves the Lifescience team from fielding time-intensive, resource-intensive questions from their clients.

More recently, Jaafar and his team looked at the benefits of generative AI, specifically around online surveys built to allow independent physicians to weigh in with critiques and recommendations for a particular drug. An important component of the peer review process, pharmaceutical companies reach out to physicians for real-world, patient-facing opinions on potential drugs. For Jaafar, generative AI and large-language models have allowed him to produce survey templates for online discussions among physicians as well as identify relevant experts for a specific survey.

“This was previously done entirely manually and we would just have to use our own experience and expertise to pull something together,” Jaafar says. “But with AI, we’re able to give it the background of the discussion guide we’d like to have, and it produces a very useful template that has us 80% of the way to a finalized guide.”

The team manually works on the remaining 20%.

While the team celebrates the success they have had with AI, Jaafar and Rahmani know bigger challenges await. Jaafar would like to build their own models for AI specific to their craft. Though Lifescience Dynamics can pull from its own historical data, the real value would come in more shared data from the industry. Unfortunately, he explains, the regulatory nature of health care and patient confidentiality combined with the competitive nature of the pharmaceutical industry means companies hold their own data close for a variety of reasons. A fear is that companies will continue to silo in fields of development rather than share collective data globally so that AI can learn at an exponential rate. There is simply less shareable data than other fields.

Rahmani predicts it will take more years to settle debates in pharmaceuticals over AI. For all the euphoria and excitement, there are old promises and leaders who just aren’t for technology, he says. He, however, feels confident in the future of AI as a tool to the industry’s collective success.

“I can understand why they aren’t willing to connect, but it limits the utility of AI,” Rahmani says. “Our clients engage us to give them the insight and convert insight into foresight, in the shortest time possible and in the least expensive way. These AI tools squeeze the most out of our data and bring that data alive.”

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